| Dexmedetomidine Premedication for Post-anaesthesia Sleep Disturbance
术前使用 dexmedetomidine 对术后睡眠障碍的影响 | NCT06281561 | Primary Purpose: Treatment
主要目的: 治疗 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分组设计 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重（参与者、护理提供者、研究者、结果评估者） | 23 Years to 45 Years (Adult )
23 岁至 45 岁（成人） | - Drug: Normal Saline 药物: 生理盐水
- Drug: Dexmedetomidine 药物: 德美松
| - Change from baseline sleep quality at after intervention
干预后与基线相比的睡眠质量变化 - Pittsburgh sleep quality index(PSQI)
堪培拉睡眠质量指数(PSQI) - Early recovery evaluated by Aldrete rating scale
早期恢复由 Aldrete 评分评估 - (and 1 more…) (还有 1 个...)
| | - Postoperative Sleep Disturbance
术后睡眠障碍
| 2024-05-01 |
| The Effect of Nocturnal Dexmedetomidine on Postoperative Sleep Quality and Fatigue After Major Surgery in Elderly Patients: DEXSLEEP Study
在老年患者大手术后评估夜间使用去甲肾上腺素对术后睡眠质量和疲劳的影响：DEXSLEEP 研究 | NCT06480539 | Primary Purpose: Treatment
主要目的: 治疗 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分组设计 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重（参与者、护理提供者、研究者、结果评估者） | 60 Years and older (Adult, Older Adult )
60 岁及以上（成人，老年人） | - Drug: Placebo 安慰剂
- Drug: Dexmedetomidine 药物: 德美松
| - Quality of Recovery (QoR)
恢复质量 (QoR) - Sleep-wake cycle (MCTQ) 睡眠-觉醒周期 (MCTQ)
- Sleep pattern (CSD) 睡眠模式 (CSD)
- (and 11 more…) (和另外 11 项...)
| - Ziekenhuis Oost-Limburg, Genk, Limburg, Belgium
奥斯特林布医院，根克，比利时林堡省，比利时
| - Postoperative Fatigue 术后疲劳
- Postoperative Sleep Disturbances
术后睡眠障碍 - Surgical Stress Response 手术应激反应
| 2024-06-06 |
| Effect of Propofol on Postoperative Sleep Quality in Elderly Patients With Sleep Disorders
丙泊酚对老年睡眠障碍患者术后睡眠质量的影响 | NCT05325762 | Primary Purpose: Treatment
主要目的: 治疗 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分组设计 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重（参与者、护理提供者、研究者、结果评估者） | 60 Years to 85 Years (Adult, Older Adult )
60 岁至 85 岁（成人，老年人） | - Drug: Propofol 药物: 丙泊酚
- Drug: Dexmedetomidine 药物: 德美松
- Drug: Saline 药物: 氯化钠
| - Sleep improvement efficiency
睡眠改善效率 - Safety of drug use 药物使用的安全性
- Sleep scale assessment 睡眠量表评估
| - Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing, China
北京天坛医院，首都医科大学，北京，中国 - Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
同济医院，同济医学院，华中科技大学，武汉，湖北，中国 - The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China
中国医科大学附属第一医院，沈阳，辽宁，中国 - West China Hospital, Sichuan University, Chengdu, Sichuan, China
西南医院，四川大学，成都，四川，中国
| | 2022-12-01 |
| Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery
氯胺酮- Dexmedetomidine 组合和大手术后非心脏手术引起的睡眠障碍New 新 | NCT06859892 | Primary Purpose: Prevention
主要目的: 预防 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分组设计 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重（参与者、护理提供者、研究者、结果评估者） | 18 Years and older (Adult, Older Adult )
18 岁及以上（成人，老年人） | - Drug: Dexmedetomidine-esketamine combination
药物: 双异丙酚-埃克赛塔明组合 - Drug: Placebo 安慰剂
| - Incidence of sleep disturbances within 3 days after surgery
术后 3 天内睡眠紊乱的发生率 - Quality of recovery at 24 hours after surgery
术后 24 小时内的恢复质量 - Subjective sleep quality in the first 3 nights after surgery.
第 1 至第 3 个晚上术后睡眠质量。 - (and 3 more…) (还有 3 个更多……)
| - Peking University First Hospital, Beijing, China
北京大学第一医院，中国北京
| - Adults 成人
- Major Noncardiac Surgery 非心脏手术
- Dexmedetomidine 德西地米松
- 2 more 两个更多
| 2025-03-18 |
| Providing "Good Sleep" for ICU Sedation
提供“良好睡眠”用于 ICU 镇静 | NCT01342328 | Primary Purpose: Other 主要目的: 其他 Allocation: Randomized 分配: 随机化 Intervention Model: Single Group Assignment
干预模型: 单组分配 Masking: None (Open Label)
保密方式: 无（开放标签） | 18 Years to 45 Years (Adult )
18 岁至 45 岁（成人） | - Other: Normal saline infusion
其他: 正常生理盐水输注 - Drug: Dexmedetomidine 药物: 德美松
- Drug: Propofol 药物: 丙泊酚
| - Compare the electroencephalography features of sleep produced by three sleep-induced regimens
比较由三种睡眠诱导方案产生的睡眠的脑电图特征 - Compare the magnetoencephalography features of sleep produced by three sleep induced regimens
比较由三种睡眠诱导方案产生的睡眠的脑磁图特征
| - University of California San Francisco, San Francisco, California, United States
加利福尼亚大学旧金山分校，加利福尼亚州，美国
| | 2012-05 |
| DISE in Pediatric Sleep Disordered Breathing
DISE 在儿科睡眠呼吸障碍中的研究 | NCT06756971 | Primary Purpose: Diagnostic
主要目的: 诊断 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分组设计 Masking: Triple (ParticipantInvestigatorOutcomes Assessor)
遮盲: 三重（参与者、研究者、评估者） | 1 Month to 18 Years (Child, Adult )
1 个月至 18 岁（儿童，成人） | - Drug: Propofol 药物: 丙泊酚
- Drug: Dexmedetomidine 药物: 德美松
| - Comparing Dexmedetomidine and Propofol for successful DISE (Drug Induced Sleep Endoscopy) procedure in-terms regarding which drug works better without causing side effects
比较地塞米松和丙泊酚在药物诱导睡眠内镜检查中的有效性，看哪种药物在不引起副作用的情况下更有效
| | - Sleep Disordered Breathing
睡眠呼吸紊乱 - Drug Induced Sleep Disorder
药物引起的睡眠障碍
| 2022-06-01 |
| Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients
用于减少心脏手术患者术后谵妄的 dexmedetomidine | NCT06619912 | Primary Purpose: Prevention
主要目的: 预防 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分组设计 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重（参与者、护理提供者、研究者、结果评估者） | 18 Years and older (Adult, Older Adult )
18 岁及以上（成人，老年人） | - Drug: Dexmedetomidine nasal spray
药物: 双氢埃托啡鼻喷雾剂
| - Postoperative delirium occurrence
术后谵妄发生率 - Delirium severity measurement
谵妄严重程度测量 - Duration of delirium 持续的谵妄
- (and 5 more…) (和另外 5 项……)
| - Xijing Hospital, Xi'an, Shaanxi, China
西安交通大学第一附属医院，陕西西安
| - Postoperative Delirium 术后谵妄
- Preoperative Sleep Disorder
术前睡眠障碍
| 2025-03-03 |
| Investigation of Sleep in the Intensive Care Unit
强化护理单元中的睡眠研究 | NCT03355053 | Primary Purpose: Prevention
主要目的: 预防 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分组设计 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重（参与者、护理提供者、研究者、结果评估者） | 50 Years and older (Adult, Older Adult )
50 岁及以上（成人，老年人） | - Drug: Dexmedetomidine 药物: 德美松
- Drug: Placebo 安慰剂
| - In-hospital Delirium-free days (IH-DFDs)
院内无谵妄日数（IH-DFDs） - ICU-Delirium-free days (ICU-DFDs)
重症监护病房无谵妄日数（ICU-DFDs） - Sleep Quantity-quality (SQ) score
睡眠质量和数量（SQ）评分 - (and 2 more…) (和更多...)
| - Massachusetts General Hospital, Boston, Massachusetts, United States
马萨诸塞州波士顿，美国麻省总医院
| | 2018-05-29 |
| Double-Blind, Placebo-Controlled, Crossover Study With Roll-over Extension of Two RE03 Doses for PTSD Sleep Disturbances
双盲、安慰剂对照、交叉研究，包含两种 RE03 剂量的延续试验，用于治疗 PTSD 睡眠障碍 | NCT06685965 | Primary Purpose: Treatment
主要目的: 治疗 Allocation: Randomized 分配: 随机化 Intervention Model: Crossover Assignment
干预模型: 交叉分配 Masking: Triple (ParticipantCare ProviderInvestigator)
三重掩蔽（参与者护理提供者研究者） | 18 Years to 64 Years (Adult )
18 岁到 64 岁（成人） | - Drug: RE03 药物: RE03
- Drug: Placebo 安慰剂
| - Time spent in sleep stages N2 + N3 [%]
睡眠阶段 N2+N3 所占时间[%] - REM fragmentation index REM 期片段化指数
- REM density REM 密度
- (and 2 more…) (和更多...)
| - Human Sleep Pharmacology, University of Zurich, Zürich, ZH, Switzerland
人类睡眠药理学，瑞士苏黎世大学，苏黎世，ZH，瑞士
| - Posttraumatic Stress Disorder (PTSD)
创伤后应激障碍（PTSD） - Sleep Disturbances and Insomnia
睡眠障碍和失眠
| 2025-04-01 |
| A Pilot Study of Effect of Dexmedetomidine on Sleep and Inflammation in Critically Ill Patients
丁丙诺啡对重症患者睡眠和炎症影响的试点研究 | NCT00405847 | Primary Purpose: Treatment
主要目的: 治疗 Allocation: Randomized 分配: 随机化 Intervention Model: Crossover Assignment
干预模型: 交叉分配 Masking: Double 掩蔽：双盲 | 21 Years to 85 Years (Adult, Older Adult )
21 岁至 85 岁（成人，老年人） | - Drug: Dexmedetomidine 药物: 德美松
| - Sleep disruption (Arousals, awakenings and sleep efficiency measured by polysomnography)
睡眠中断（通过多导睡眠图测量的觉醒、觉醒次数和睡眠效率） - Circulating levels of Inflammatory cytokines (TNF-alpha, IL-1, IL-6, IL-10)
循环中的炎症细胞因子水平（TNF-α、IL-1、IL-6、IL-10）
| - Southern Arizona VA Healthcare System, Tucson, Arizona, United States
美国亚利桑那州图森退伍军人事务南方亚利桑那卫生医疗系统
| - Sleep 睡眠
- Critical Illness 重症疾病
| 2006-07 |
| Dex as Analgesic Adjuvant in OSA Patients
Dex 作为镇痛辅助剂在 OSA 患者中的应用 | NCT03613558 | Primary Purpose: Treatment
主要目的: 治疗 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分组设计 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重（参与者、护理提供者、研究者、结果评估者） | 18 Years and older (Adult, Older Adult )
18 岁及以上（成人，老年人） | - Drug: Dexmedetomidine 药物: 德美松
- Drug: Placebo 药物: 安慰剂
| - Pain Score
- Pain Score
- Nausea
- (and 5 more…) (和另外 5 项……)
| - Montefiore Medical Center, Bronx, New York, United States
蒙特菲奥里医疗中心，纽约市，美国
| - Obstructive Sleep Apnea 阻塞性睡眠呼吸暂停
| 2014-07 |
| Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea
有阻塞性睡眠呼吸暂停病史的儿童中使用 dexmedetomidine 和 propofol | NCT01344759 | Primary Purpose: Treatment
主要目的: 治疗 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分配 Masking: None (Open Label)
掩蔽: 无（开放标签） | 12 Months to 25 Years (Child, Adult )
12 个月至 25 岁（儿童，成人） | - Drug: Dexmedetomidine 药物: 双异丙酚
- Drug: Propofol 药物: 异丙酚
| - Cross Sectional Area of the Pharyngeal Airway
- Obstructive Index Until Recovery Room Discharge
- Respiratory Disturbance Index
- (and 2 more…)
| - Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
| | 2009-06 |
| Dexmedetomidine Supplemented Analgesia in Patients at High-risk of Obstructive Sleep Apnea
在高风险阻塞性睡眠呼吸暂停患者中补充丁丙诺啡镇痛 | NCT04608331 | Primary Purpose: Prevention
主要目的: 预防 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
平行分组设计 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
quadruple（参与者、研究者、调查员、结果评估者）掩蔽 | 18 Years to 80 Years (Adult, Older Adult )
18 岁至 80 岁（成人、老年人） | - Drug: Dexmedetomidine 药物: 德美多睫明
- Drug: Placebo 药物: 醒目剂
| - The percentage of non-rapid eye movement stage 2 (N2) sleep.
- Total sleep duration.
- Sleep efficiency.
- (and 8 more…)
| - Dong-Xin Wang, Beijing, Beijing, China
| - Obstructive Sleep Apnea
- Analgesia
- Dexmedetomidine
- 2 more
| 2021-01-29 |
| Sedative Effects in Obstructive Sleep Apnea
阻塞性睡眠呼吸暂停的镇静作用 | NCT01733043 | Primary Purpose: Treatment
主要目的: 治疗 Allocation: Randomized 分配: 随机化 Intervention Model: Crossover Assignment
干预模型: 交叉分配 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重掩蔽（参与者、护理提供者、研究者、结果评估者） | 18 Years and older (Adult, Older Adult )
18 岁及以上（成人、老年人） | - Drug: Dexmedetomidine 药物: 德美多昔布
- Drug: Placebo 安慰剂
| - Apnea Hypopnea Index
- Sleep Architecture
| | | 2015-03 |
| Does Nightly Dexmedetomidine Improve Sleep and Reduce Delirium in ICU Patients?
夜间使用德美他嗪能否改善睡眠并减少 ICU 患者的谵妄？ | NCT01791296 | Primary Purpose: Prevention
主要目的: 预防 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分配 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重掩蔽（参与者护理提供者研究者结果评估者） | 18 Years to 80 Years (Adult, Older Adult )
18 岁至 80 岁（成人，老年人） | - Drug: Dexmedetomidine 药物: 德美他淀
- Other: Placebo 其他: 醒目剂
| - Development of delirium
- Development of subsyndromal delirium
| - Tufts Medical Center, Boston, Massachusetts, United States
- Maisonneuve Rosemont Hospital, Montréal, Quebec, Canada
| - Sleep Deprivation
- Delirium
| 2011-01 |
| Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep
使用德美他淀诱导睡眠减轻 ICU 神经功能障碍 | NCT02856594 | Primary Purpose: Treatment
主要目的: 治疗 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分配 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重掩蔽（参与者_研究者_评估者_结果评估者） | 60 Years and older (Adult, Older Adult )
60 岁及以上（成人，老年人） | - Drug: Dexmedetomidine 药物: 德美松
- Drug: Placebo 药物: 安慰剂
| - Incidence of Delirium
- ICU Delirium/Coma-free Days
- Severity of Delirium
- (and 5 more…)
| - Massachusetts General Hospital, Boston, Massachusetts, United States
| - Postoperative Delirium
- Sleep
- Anesthesia
| 2017-03-06 |
| Sedation in Patients at Risk for Upper Airway Collapse
患有上呼吸道塌陷风险患者的镇静 | NCT01045122 | Allocation: Randomized 分配: 随机化 Intervention Model: Crossover Assignment
干预模型: 交叉分配 Masking: Double (ParticipantInvestigator)
保密方式: 双盲（参与者和研究者） | 18 Years to 75 Years (Adult, Older Adult )
18 岁至 75 岁（成人，老年人） | - Drug: Propofol 药物: 异丙酚
- Drug: Dexmedetomidine 药物: 德美多定
| - Respiratory Disturbance Index
| - University of Rochester, Rochester, New York, United States
| | 2006-12 |
| Dexmedetomidine Added to Propofol for Drug Induced Sleep Endoscopy
德美多定与丙泊酚联合用于药物诱导睡眠内镜检查 | NCT03091894 | Primary Purpose: Supportive Care
主要目的: 支持性护理 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
平行分组设计 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重（参与者_研究者_调查者_结果评估者） | 18 Years and older (Adult, Older Adult )
18 岁及以上（成人_老年人） | - Drug: Propofol 药物: 异丙酚
- Drug: Dexmedetomidine 药物: 德美他淀
| - success of sedation
- time until sufficient sedation
| - Zagazig university, Zagazig, Sharkia, Egypt
| - Obstructive Sleep Apnea of Adult
| 2017-04-09 |
| Dexmedetomidine Cycling and Sleep in the Pediatric ICU
德美他淀循环和儿科 ICU 的睡眠 | NCT05003102 | Primary Purpose: Treatment
主要目的: 治疗 Allocation: Randomized 分配: 随机化 Intervention Model: Crossover Assignment
干预模型: 交叉分配 Masking: Single (Outcomes Assessor)
遮盲: 单盲（结果评估者） | 12 Years to 17 Years (Child )
12 岁至 17 岁（儿童） | - Drug: Dexmedetomidine Hydrochloride - Cycling
药物: 氯化去甲肾上腺素 - 轮换 - Drug: Fentanyl - PICU Standard
药物: 芬太尼 - 儿科重症监护室标准 - Drug: Dexmedetomidine Hydrochloride - PICU Standard
药物: 氯化去甲肾上腺素 - 儿科重症监护室标准
| - Change in total sleep time as seen via an 8-lead polysomnogram
- Change in total time in different stages of sleep as seen via an 8-lead polysomnogram
- Change in arousal index as seen via an 8-lead polysomnogram
- (and 2 more…)
| - Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, United States
| - Critical Illness
- Sedation Complication
- Delirium
| 2023-02-20 |
| Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy
减少儿童扁桃体切除术和腺样体切除术后出现的激动，并提供镇痛 | NCT00468052 | Primary Purpose: Prevention
主要目的: 预防 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分组设计 Masking: Single (Participant)
掩蔽: 单盲 (参与者) | 2 Years to 10 Years (Child )
2 岁至 10 岁（儿童） | - Drug: dexmedetomidine 药物: dexmedetomidine
- Drug: fentanyl 药物: fentanyl
| - Emergence Agitation and Pain
- Duration of Agitation
- Hemodynamic Stability
- (and 4 more…)
| - UMDNJ University Hospital, Newark, New Jersey, United States
| | 2007-03 |
| Efficacy and Stability of Dexmedetomidine Sedation Compared to Propofol Sedation in the Drug Induced Sleep Endoscopy
比较 dexmedetomidine 镇静与 propofol 镇静在药物诱导睡眠内镜检查中的有效性和稳定性 | NCT03892122 | Primary Purpose: Diagnostic
主要目的: 诊断 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分配 Masking: None (Open Label)
掩蔽: 无（开放标签） | 18 Years to 65 Years (Adult, Older Adult )
18 岁至 65 岁（成人，老年人） | - Drug: Propofol Fresenius 药物: Fresenius 丙泊酚
- Drug: Dexmedetomidine 药物: 德美多昔康
| - oxygen saturation variation during DISE
- hert rate variation during DISE
- systolic and diastolic blood pressure variation during DISE
- (and 2 more…)
| - U.O.C. Otorinolaringoiatria Ospedale Di Barletta, Barletta, BAT, Italy
| | 2019-03-22 |
| Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients
低剂量德美多昔康对 ICU 机械通气患者睡眠质量的影响 | NCT03335527 | Primary Purpose: Prevention
主要目的: 预防 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分配 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重掩蔽（参与者护理提供者研究者结果评估者） | 18 Years and older (Adult, Older Adult )
18 岁及以上（成人，老年人） | - Drug: Dexmedetomidine 药物: 德美松
- Drug: Placebo (normal saline)
药物: 安慰剂（生理盐水）
| - Sleep quality during the night of surgery.
- Incidence of delirium within the first 7 days after surgery.
- Sleep quality within the first 7 days after surgery.
- (and 12 more…)
| - Peking University First Hospital, Beijing, Beijing, China
| - Aged
- Postoperative Period
- Intensive Care Units
- 3 more
| 2017-11-17 |
| Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
在儿科阻塞性睡眠呼吸暂停中，右美托咪定与丙泊酚镇静用于药物诱导睡眠内镜的比较 | NCT05303987 | Primary Purpose: Diagnostic
主要目的: 诊断 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分组 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重盲法（参与者、研究者、评估者、结果评估者） | 3 Years to 11 Years (Child )
3 岁至 11 岁（儿童） | - Drug: Propofol sedation 药物: 丙泊酚镇静
- Drug: Dexmedetomidine sedation
药物: 布托啡诺镇静
| - Mean obstruction score at the tongue base
| - University of Michigan, Ann Arbor, Michigan, United States
| | 2022-10-05 |
| Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery
布托啡诺用于减缓胃肠道手术后的术后疼痛 | NCT02213159 | Primary Purpose: Treatment
主要目的: 治疗 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
干预模型: 平行分配 Masking: Double (ParticipantOutcomes Assessor)
掩蔽: 双盲（参与者和评估者） | 18 Years to 70 Years (Adult, Older Adult )
18 岁至 70 岁（成人，老年人） | - Drug: Dexmedetomidine 药物: 德美他明
- Drug: Morphine 药物: 吗啡
| - Total dose of morphine consumed in Post Anesthesia Care Unit (PACU)
- Time to first morphine requirement in PACU
- Numeric Rating Scale (NRS) for Pain
- (and 8 more…)
| - American University of Beirut Medical Center, Beirut, Lebanon
| - Obesity
- Sleep Apnea
- Diabetes
- 1 more
| 2014-07 |
| Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA
在高风险 OSA 患者中，小剂量 Dexmedetomidine-Esketamine 补充镇痛 | NCT06566482 | Primary Purpose: Prevention
主要目的: 预防 Allocation: Randomized 分配: 随机化 Intervention Model: Parallel Assignment
平行分组设计 Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
quadruple (参与者研究者研究者结果评估者) 遮盲 | 18 Years to 80 Years (Adult, Older Adult )
18 岁至 80 岁（成人，老年人） | - Drug: Dexmedetomidine-esketamine combination
药物: 右美托咪定-埃克塞塔明组合 - Drug: Placebo 药物: 安慰剂
| - Subjective sleep quality during the first night after surgery.
- Sleep structure parameters during the first night after surgery.
- Cumulative subjective sleep quality score after surgery
- (and 3 more…)
| - Peking University First Hospital, Beijing, Beijing, China
| - Obstructive Sleep Apnea
- Surgery
- Dexmedetomidine
- 2 more
| 2024-09-11 |
| A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial | NCT01895348 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant)
| 20 Years to 60 Years (Adult )
| - Drug: Propofol
- Drug: propofol-remifentanil
- Drug: Dexmedetomidine-remifentanil
| | - Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of
| | 2012-07 |
| Opioid-Free Anesthetic for Tonsillectomy | NCT04528173 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (ParticipantInvestigatorOutcomes Assessor)
| 2 Years to 18 Years (Child, Adult )
| - Drug: Ketorolac
- Drug: Dexmedetomidine
- Drug: Morphine
- 1 more
| - Mean FLACC (Face, Legs, Activity, Cry, Consolability) Pain Score
- Number of Participants With Nausea, Vomiting, Pruritis
- Number of Participants Who Sought Unplanned Medical Attention
- (and 5 more…)
| - The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
- University of Tennessee Health Science Center; St. Jude Children's Research Hospital, Memphis, Tennessee, United States
| - Anesthesia
- Opioid Use
- Tonsillitis
- 2 more
| 2020-07-22 |
| Dexmedetomidine Enhancing the Recovery After Cardiac Surgery New | NCT06907277 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant)
| 40 Years to 65 Years (Adult, Older Adult )
| - Drug: Dexmedetomidine
- Drug: Fentanyl
- Drug: Lidocain
| - Significant Enhancement of Post Operative Recovery Levels After Dexmedetomidine Administration in Cardiac Surgery.
| - Benha University, Banhā, El Qalyoubia, Egypt
| | 2024-08-30 |
| DexmedetOmidine Complement Treats Chronic insOmnia and Improves Circadian Rhythm (DOCTOR) | NCT04635098 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (ParticipantInvestigator)
| 18 Years to 65 Years (Adult, Older Adult )
| - Drug: dexmedetomidine
- Drug: saline
| - Sleep efficiency
- BMAL1
- Brain functional connectivity
- (and 14 more…)
| - Ruijin Hospital, Shanghai, Shanghai, China
| | 2021-05-14 |
| The Comparison of Dexmedetomidine and Midazolam for the Sleep in Intensive Care Unit | NCT01966315 | Observational Model: Case-Control Time Perspective: Prospective | 18 Years and older (Adult, Older Adult )
| | - The differences of sleep stage, sleep efficiency, arousal index and delirium between dexmedetomidine group and midazolam group
| - Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of
| - Poor Quality Sleep
- Sleep Deprivation
- Sleep Arousal Disorders
- 1 more
| 2013-10 |
| Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle New | NCT06824077 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (ParticipantOutcomes Assessor)
| 18 Years and older (Adult, Older Adult )
| - Drug: Dexmedetomidine
- Other: Control (placebo) group
| - Recruitment rate
- Protocol Adherence
| | - Sleep
- Delirium
- ICU Hospitalization
| 2025-03-01 |
| Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery New | NCT06778811 | Primary Purpose: Prevention Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (ParticipantCare ProviderOutcomes Assessor)
| 40 Years to 75 Years (Adult, Older Adult )
| - Drug: Intraoperative infusion of dexmedetomidine
- Drug: Intraoperative infusion of esketamine
- Drug: Saline control
| - Sleep Quality
- postoperative pain
- Record postoperative analgesic medications used and the amount used for postoperative pain
- (and 3 more…)
| - Nanjing First Hospital, Nanjing, Jiangsu, China
- Nanjing First Hospital，Nanjing Medical University, Nanjing, Jiangsu, China
| - Sleep Wake Disorders
- Esketamine and the Quality of Recovery
- Dexmedetomidine
| 2024-10-11 |
| Safety and Efficacy of Esmketamine Versus Dexmedetomidine | NCT04877639 | Primary Purpose: Other Allocation: Randomized Intervention Model: Sequential Assignment Masking: Single (Participant)
| 3 Years to 12 Years (Child )
| - Drug: Esmketamine,Dexmedetomidine
| | - Zhongnan Hospital, Wuhan, Hubei, China
| | 2021-05-01 |
| The Addition of Dexmedetomidine on Postoperative Sleep for Middle-aged and Elderly Patients With Gastric Cancer | NCT03117023 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
| 55 Years and older (Adult, Older Adult )
| | - sleep time
- pain score
- daily sufentanil consumption
- (and 3 more…)
| | | 2017-04-15 |
| Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II) | NCT06192615 | Primary Purpose: Prevention Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
| 60 Years and older (Adult, Older Adult )
| - Drug: Intravenous Dexmedetomidine
- Drug: Sublingual Dexmedetomidine
- Drug: Intravenous Placebo
- 1 more
| - Delirium
- Delirium
- Delirium Severity
- (and 9 more…)
| - Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
- University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
- University of Maryland School of Medicine, Baltimore, Maryland, United States
- Massachusetts General Hospital, Boston, Massachusetts, United States
- (and 8 more…)
| | 2025-01-06 |
| The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation | NCT02162433 | Primary Purpose: Prevention Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
| 3 Years to 16 Years (Child )
| - Drug: Normal Saline
- Drug: Dexmedetomidine
| - Number of Participants With Respiratory Complications
- Number of Participants With Emergence Agitation
- Number of Participants With Postoperative Nausea and Vomiting (PONV)
- (and 4 more…)
| - MEEI, Boston, Massachusetts, United States
| - Adenotonsillar Hypertrophy
- Obstructive Sleep Apnea
- Tonsillitis
- 1 more
| 2015-03 |
| Establishment of Ideal IV Sedative Regimen for Successful Fiberoptic Bronchoscopy in Assessing the Site, Severity of Sleep Apnea Syndrome | NCT02148432 | Primary Purpose: Other Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (ParticipantCare ProviderInvestigator)
| 20 Years to 60 Years (Adult )
| - Drug: dexmedetomidine infusion rate, 0.5 mcg/kg/hr
- Drug: dexmedetomidine infusion rate, 1.0 mcg/kg/hr
| | - Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of
| | 2014-05-19 |
| Intranasal Dexmedetomidine and Zolpidem for Treatment of Primary Insomnia | NCT05615727 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Crossover Assignment Masking: Double (ParticipantOutcomes Assessor)
| 18 Years to 25 Years (Adult )
| - Drug: Dexmedetomidine
- Drug: Zolpidem
- Other: Placebo
| - Sleep onset latency
- Incidence of wakening after sleep onset; Sleep quality; Wake time during sleep
| - HKU Li Ka Shing Faculty of Medicine, Hong Kong, Guangdong, China
| | 2022-09-01 |
| Sleep Intervention During Acute Lung Injury | NCT01050699 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Crossover Assignment Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
| 18 Years to 85 Years (Adult, Older Adult )
| - Drug: Dexmedetomidine
- Drug: Midazolam and Fentanyl
| - Specific Aim 1: To assess the short-term effect of an α2 adrenergic agent on sleep quality in critically ill patients with ALI/ARDS.
- Specific Aim 2: To assess the short-term effect of an α2 adrenergic agent on sleep-modulating inflammatory cytokines in critically ill patients with ALI/ARDS.
- Specific aim 3: To determine the effect of α2 adrenergic agent on the in-vitro production of sleep-modulating inflammatory cytokines by peripheral blood mononuclear cells of patients with ALI/ARDS.
| - Southern Arizona VA Health Care System, Tucson, Arizona, United States
- University Medical Center, Tucson, Arizona, United States
| - Critical Illness
- Sleep
- Acute Lung Injury
- 1 more
| 2009-08 |
| Dexmedetomidine and Melatonin for Sleep Induction for EEG in Children | NCT04665453 | Primary Purpose: Diagnostic Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) | 1 Year to 20 Years (Child, Adult )
| - Diagnostic Test: Electroencephalography
- Diagnostic Test: Monitoring of vital functions
- Drug: Melatonin 0,1mg/kg oral syrup
- 2 more
| - Comparison of the three medical interventions on sleep initiation
- Comparison of the three medical interventions on the depth of sleep and the most prominent sleep stage on EEG
- Comparison of the three medical interventions on respiratory rate
- (and 3 more…)
| - University Medical Centre Ljubljana, Ljubljana, Slovenia
| - Electroencephalography
- Child
- Dexmedetomidine
- 3 more
| 2020-09-01 |
| Dexmedetomidine-esketamine Combined Nasal Administration and Perioperative Sleep Quality | NCT05732064 | Primary Purpose: Prevention Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
| 50 Years and older (Adult, Older Adult )
| - Drug: Dexmedetomidine
- Drug: Esketamine
- Drug: Normal saline
| - Subjective sleep quality (the night of surgery)
- Subjective sleep quality (the night before and the first night after surgery)
- Objective sleep quality - total sleep time
- (and 5 more…)
| - Peking University First Hospital, Beijin, Bejing, China
| - Breast Cancer
- Perioperative Period
- Dexmedetomidine
- 2 more
| 2023-05-22 |
| How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units | NCT00826553 | Primary Purpose: Other Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor)
| 18 Years and older (Adult, Older Adult )
| - Drug: Dexmedetomidine
- Drug: GABA agonist
| - Time spent in standard sleep stages (N1, N2, N3, REM).
- Time spent in atypical sleep.
- Presence of burst suppression.
| - Vanderbilt University Medical Center, Nashville, Tennessee, United States
| - Delirium
- Respiratory Failure
| 2009-01 |
| Brain Tumor Surgery and Postoperative Delirium New | NCT06863064 | Primary Purpose: Prevention Allocation: N/A Intervention Model: Single Group Assignment Masking: None (Open Label) | 18 Years to 80 Years (Adult, Older Adult )
| - Drug: Dexmedetomidine
- Drug: Normal Saline
| - Assessment and Documentation of Delirium
- Assessment and Documentation of Delirium
- Assessment and Documentation of Delirium
- (and 2 more…)
| - Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan
| | 2025-03-01 |
| Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk | NCT04817033 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Factorial Assignment Masking: Double (InvestigatorOutcomes Assessor)
| 18 Years to 80 Years (Adult, Older Adult )
| - Procedure: Spinal anesthesia with intraoperative dexmedetomidine sedation
- Procedure: Spinal anesthesia with intraoperative midazolam sedation
- Drug: Dexmedetomidine
- 1 more
| - Airway complications
- Coughing and restlessness
- Cardiorespiratory polygraphy
- (and 7 more…)
| - University Hospital Split, Split, Croatia
| - Anesthesia
- Anesthesia Complication
- Osa Syndrome
- 5 more
| 2021-04-01 |
| Effect of Ketorolac on Post Adenotonsillectomy Pain | NCT03467750 | Primary Purpose: Supportive Care Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Care Provider)
| 2 Years to 18 Years (Child, Adult )
| - Drug: Ketorolac
- Drug: Standard of Care
| - Post-Anesthesia Care Unit (PACU) Morphine Requirements
- Face, Legs, Activity, Cry, Consolability (FLACC) Scale Score
- Post-Anesthesia Care Unit (PACU) Recovery Time
- (and 2 more…)
| - Childrens Healthcare of Atlanta, Egleston, Atlanta, Georgia, United States
| | 2018-07-19 |
| Dexmedetomidine After Cardiac Surgery for Prevention of Delirium | NCT03477344 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
| 65 Years and older (Older Adult )
| - Drug: Dexmedetomidine
- Drug: Sodium chloride 0.9%
| - Delirium
- agitation with be assessed using the Richmond agitation and sedation score
- length of ICU stay
- (and 13 more…)
| - Angers university hospital, Angers, France
- CHRU de Brest, Brest, France
- Clermont Ferrand university hospital, Clermont-Ferrand, France
- CHU de Grenoble, Grenoble, France
- (and 5 more…)
| | 2019-01-04 |
| Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy | NCT02987985 | Primary Purpose: Prevention Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (ParticipantInvestigatorOutcomes Assessor)
| up to 12 Years (Child )
| - Drug: Acetaminophen, gabapentin
- Drug: Acetaminophen
- Drug: Ketamine , Lidocaine , Dexmedetomidine
- 4 more
| - Respiratory depression
- Quantified opioid consumption
- Pediatric Agitation Emergence Delirium (PAED) scale
- (and 3 more…)
| - Royal University Hospital, Saskatoon, Saskatchewan, Canada
| - Anesthesia
- General Anesthesia
- Analgesics, Opioid
- 14 more
| 2017-10-15 |
| Correlation Endoscopic View of Airway Obstruction With RRa in OSA Patients Under DEX Monitored With SedLine EEG | NCT02639884 | Primary Purpose: Other Allocation: N/A Intervention Model: Single Group Assignment Masking: None (Open Label) | 19 Years and older (Adult, Older Adult )
| - Device: SedLine EEG
- Device: RRa monitoring
| - Number of Subjects in Which Electroencephalogram (EEG) Signals is Collected
- Number of Subjects in Which Acoustic Respiratory Rate (RRa) Signals is Collected
| - Stanford University Medical Center, Stanford, California, United States
| - Obstructive Sleep Apnea (OSA)
| 2015-12 |
| Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils | NCT06258837 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor)
| 2 Years to 17 Years (Child )
| - Procedure: DISE-Directed Surgery
- Procedure: Adenotonsillectomy
| - Change from Baseline Polysomnography Measures: Obstructive Apnea-Hypopnea Index (oAHI) at 6 months
- Change from Baseline Polysomnography Measures: Total Apnea-Hypopnea Index (AHI) at 6 months
- Change from Baseline Polysomnography Measures: REM Apnea-Hypopnea Index (REM AHI) at 6 months
- (and 10 more…)
| - University of Michigan, Ann Arbor, Michigan, United States
- Oregon Health and Science University, Portland, Oregon, United States
| - Otolaryngological Disease
- Obstructive Sleep Apnea
| 2024-10-04 |
| Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management | NCT01725607 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor)
| 18 Years to 65 Years (Adult, Older Adult )
| - Drug: general anesthesia combined with dexmedetomidine infusion
- Procedure: general anesthesia combined with TEA
| - inflammatory cytokine secretion and postoperative sleep quality
- amine secretion during the surgical period and hemodynamic stability
| - Department of Anesthesiology, the First Hospital of China Medical University, Shenyang, Liaoning, China
| - General Anesthesia, Thoracic Epidural Anesthesia
| 2013-01 |
| Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS) | NCT05508971 | Primary Purpose: Treatment Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor)
| 2 Years to 17 Years (Child )
| - Procedure: DISE-Directed Surgery
- Procedure: Adenotonsillectomy
| - Change from Baseline Polysomnography Measures: oAHI at 6 months
- Change from Baseline Polysomnography Measures: AHI at 6 months
- Change from Baseline Polysomnography Measures: REM AHI at 6 months
- (and 10 more…)
| - Colorado Children's Hospital, Aurora, Colorado, United States
- University of Michigan, Ann Arbor, Michigan, United States
- Cincinnati Children's Hospital, Cincinnati, Ohio, United States
- Oregon Health and Science University, Portland, Oregon, United States
- (and 3 more…)
| - Obstructive Sleep Apnea
- Down Syndrome
| 2023-08-02 |
