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Viewing 1-51 out of 51 studies
正在查看 1-51 共 51 项研究

Showing results for: Sleep Disorder | Dexmedetomidine
显示结果为: 睡眠障碍 | 布托啡诺

Synonyms of conditions or disease (7)   条件或疾病的同义词 (7)
 
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Study Title   研究标题 NCT Number   NCT 编号 Study Design   研究设计 Age   年龄 Interventions   干预措施 Outcome Measures   结果衡量标准 Locations   地点 Conditions   条件 Study Start   研究开始
1
Dexmedetomidine Premedication for Post-anaesthesia Sleep Disturbance
术前使用 dexmedetomidine 对术后睡眠障碍的影响
NCT06281561
Primary Purpose: Treatment
主要目的: 治疗
Allocation: Randomized  分配: 随机化
Intervention Model: Parallel Assignment
干预模型: 平行分组设计
Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
掩蔽: 四重(参与者、护理提供者、研究者、结果评估者)
23 Years to 45 Years (Adult )
23 岁至 45 岁(成人)
  • Drug: Normal Saline  药物: 生理盐水
  • Drug: Dexmedetomidine  药物: 德美松
  • Change from baseline sleep quality at after intervention
    干预后与基线相比的睡眠质量变化
  • Pittsburgh sleep quality index(PSQI)
    堪培拉睡眠质量指数(PSQI)
  • Early recovery evaluated by Aldrete rating scale
    早期恢复由 Aldrete 评分评估
  • (and 1 more…)  (还有 1 个...)
    • Postoperative Sleep Disturbance
      术后睡眠障碍
    2024-05-01
    2
    The Effect of Nocturnal Dexmedetomidine on Postoperative Sleep Quality and Fatigue After Major Surgery in Elderly Patients: DEXSLEEP Study
    在老年患者大手术后评估夜间使用去甲肾上腺素对术后睡眠质量和疲劳的影响:DEXSLEEP 研究
    NCT06480539
    Primary Purpose: Treatment
    主要目的: 治疗
    Allocation: Randomized  分配: 随机化
    Intervention Model: Parallel Assignment
    干预模型: 平行分组设计
    Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
    掩蔽: 四重(参与者、护理提供者、研究者、结果评估者)
    60 Years and older (AdultOlder Adult )
    60 岁及以上(成人,老年人)
    • Drug: Placebo  安慰剂
    • Drug: Dexmedetomidine  药物: 德美松
    • Quality of Recovery (QoR)
      恢复质量 (QoR)
    • Sleep-wake cycle (MCTQ)  睡眠-觉醒周期 (MCTQ)
    • Sleep pattern (CSD)  睡眠模式 (CSD)
    • (and 11 more…)  (和另外 11 项...)
    • Ziekenhuis Oost-Limburg, Genk, Limburg, Belgium
      奥斯特林布医院,根克,比利时林堡省,比利时
    • Postoperative Fatigue  术后疲劳
    • Postoperative Sleep Disturbances
      术后睡眠障碍
    • Surgical Stress Response  手术应激反应
    2024-06-06
    3
    Effect of Propofol on Postoperative Sleep Quality in Elderly Patients With Sleep Disorders
    丙泊酚对老年睡眠障碍患者术后睡眠质量的影响
    NCT05325762
    Primary Purpose: Treatment
    主要目的: 治疗
    Allocation: Randomized  分配: 随机化
    Intervention Model: Parallel Assignment
    干预模型: 平行分组设计
    Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
    掩蔽: 四重(参与者、护理提供者、研究者、结果评估者)
    60 Years to 85 Years (AdultOlder Adult )
    60 岁至 85 岁(成人,老年人)
    • Drug: Propofol  药物: 丙泊酚
    • Drug: Dexmedetomidine  药物: 德美松
    • Drug: Saline  药物: 氯化钠
    • Sleep improvement efficiency
      睡眠改善效率
    • Safety of drug use  药物使用的安全性
    • Sleep scale assessment  睡眠量表评估
    • Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing, China
      北京天坛医院,首都医科大学,北京,中国
    • Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
      同济医院,同济医学院,华中科技大学,武汉,湖北,中国
    • The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China
      中国医科大学附属第一医院,沈阳,辽宁,中国
    • West China Hospital, Sichuan University, Chengdu, Sichuan, China
      西南医院,四川大学,成都,四川,中国
    • Sleep Disorder  睡眠障碍
    2022-12-01
    4
    Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery
    氯胺酮- Dexmedetomidine 组合和大手术后非心脏手术引起的睡眠障碍
    New  
    NCT06859892
    Primary Purpose: Prevention
    主要目的: 预防
    Allocation: Randomized  分配: 随机化
    Intervention Model: Parallel Assignment
    干预模型: 平行分组设计
    Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
    掩蔽: 四重(参与者、护理提供者、研究者、结果评估者)
    18 Years and older (AdultOlder Adult )
    18 岁及以上(成人,老年人)
    • Drug: Dexmedetomidine-esketamine combination
      药物: 双异丙酚-埃克赛塔明组合
    • Drug: Placebo  安慰剂
    • Incidence of sleep disturbances within 3 days after surgery
      术后 3 天内睡眠紊乱的发生率
    • Quality of recovery at 24 hours after surgery
      术后 24 小时内的恢复质量
    • Subjective sleep quality in the first 3 nights after surgery.
      第 1 至第 3 个晚上术后睡眠质量。
    • (and 3 more…)  (还有 3 个更多……)
    • Peking University First Hospital, Beijing, China
      北京大学第一医院,中国北京
    • Adults  成人
    • Major Noncardiac Surgery  非心脏手术
    • Dexmedetomidine  德西地米松
    • 2 more  两个更多
    2025-03-18
    5
    Providing "Good Sleep" for ICU Sedation
    提供“良好睡眠”用于 ICU 镇静
    NCT01342328
    Primary Purpose: Other  主要目的: 其他
    Allocation: Randomized  分配: 随机化
    Intervention Model: Single Group Assignment
    干预模型: 单组分配
    Masking: None (Open Label)
    保密方式: 无(开放标签)
    18 Years to 45 Years (Adult )
    18 岁至 45 岁(成人)
    • Other: Normal saline infusion
      其他: 正常生理盐水输注
    • Drug: Dexmedetomidine  药物: 德美松
    • Drug: Propofol  药物: 丙泊酚
    • Compare the electroencephalography features of sleep produced by three sleep-induced regimens
      比较由三种睡眠诱导方案产生的睡眠的脑电图特征
    • Compare the magnetoencephalography features of sleep produced by three sleep induced regimens
      比较由三种睡眠诱导方案产生的睡眠的脑磁图特征
    • University of California San Francisco, San Francisco, California, United States
      加利福尼亚大学旧金山分校,加利福尼亚州,美国
    • Sleep Disorders  睡眠障碍
    2012-05
    6
    DISE in Pediatric Sleep Disordered Breathing
    DISE 在儿科睡眠呼吸障碍中的研究
    NCT06756971
    Primary Purpose: Diagnostic
    主要目的: 诊断
    Allocation: Randomized  分配: 随机化
    Intervention Model: Parallel Assignment
    干预模型: 平行分组设计
    Masking: Triple (ParticipantInvestigatorOutcomes Assessor)
    遮盲: 三重(参与者、研究者、评估者)
    1 Month to 18 Years (ChildAdult )
    1 个月至 18 岁(儿童,成人)
    • Drug: Propofol  药物: 丙泊酚
    • Drug: Dexmedetomidine  药物: 德美松
    • Comparing Dexmedetomidine and Propofol for successful DISE (Drug Induced Sleep Endoscopy) procedure in-terms regarding which drug works better without causing side effects
      比较地塞米松和丙泊酚在药物诱导睡眠内镜检查中的有效性,看哪种药物在不引起副作用的情况下更有效
      • Sleep Disordered Breathing
        睡眠呼吸紊乱
      • Drug Induced Sleep Disorder
        药物引起的睡眠障碍
      2022-06-01
      7
      Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients
      用于减少心脏手术患者术后谵妄的 dexmedetomidine
      NCT06619912
      Primary Purpose: Prevention
      主要目的: 预防
      Allocation: Randomized  分配: 随机化
      Intervention Model: Parallel Assignment
      干预模型: 平行分组设计
      Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
      掩蔽: 四重(参与者、护理提供者、研究者、结果评估者)
      18 Years and older (AdultOlder Adult )
      18 岁及以上(成人,老年人)
      • Drug: Dexmedetomidine nasal spray
        药物: 双氢埃托啡鼻喷雾剂
      • Postoperative delirium occurrence
        术后谵妄发生率
      • Delirium severity measurement
        谵妄严重程度测量
      • Duration of delirium  持续的谵妄
      • (and 5 more…)  (和另外 5 项……)
      • Xijing Hospital, Xi'an, Shaanxi, China
        西安交通大学第一附属医院,陕西西安
      • Postoperative Delirium  术后谵妄
      • Preoperative Sleep Disorder
        术前睡眠障碍
      2025-03-03
      8
      Investigation of Sleep in the Intensive Care Unit
      强化护理单元中的睡眠研究
      NCT03355053
      Primary Purpose: Prevention
      主要目的: 预防
      Allocation: Randomized  分配: 随机化
      Intervention Model: Parallel Assignment
      干预模型: 平行分组设计
      Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
      掩蔽: 四重(参与者、护理提供者、研究者、结果评估者)
      50 Years and older (AdultOlder Adult )
      50 岁及以上(成人,老年人)
      • Drug: Dexmedetomidine  药物: 德美松
      • Drug: Placebo  安慰剂
      • In-hospital Delirium-free days (IH-DFDs)
        院内无谵妄日数(IH-DFDs)
      • ICU-Delirium-free days (ICU-DFDs)
        重症监护病房无谵妄日数(ICU-DFDs)
      • Sleep Quantity-quality (SQ) score
        睡眠质量和数量(SQ)评分
      • (and 2 more…)  (和更多...)
      • Massachusetts General Hospital, Boston, Massachusetts, United States
        马萨诸塞州波士顿,美国麻省总医院
      • Delirium  谵妄
      • Sleep  睡眠
      2018-05-29
      9
      Double-Blind, Placebo-Controlled, Crossover Study With Roll-over Extension of Two RE03 Doses for PTSD Sleep Disturbances
      双盲、安慰剂对照、交叉研究,包含两种 RE03 剂量的延续试验,用于治疗 PTSD 睡眠障碍
      NCT06685965
      Primary Purpose: Treatment
      主要目的: 治疗
      Allocation: Randomized  分配: 随机化
      Intervention Model: Crossover Assignment
      干预模型: 交叉分配
      Masking: Triple (ParticipantCare ProviderInvestigator)
      三重掩蔽(参与者护理提供者研究者)
      18 Years to 64 Years (Adult )
      18 岁到 64 岁(成人)
      • Drug: RE03  药物: RE03
      • Drug: Placebo  安慰剂
      • Time spent in sleep stages N2 + N3 [%]
        睡眠阶段 N2+N3 所占时间[%]
      • REM fragmentation index  REM 期片段化指数
      • REM density  REM 密度
      • (and 2 more…)  (和更多...)
      • Human Sleep Pharmacology, University of Zurich, Zürich, ZH, Switzerland
        人类睡眠药理学,瑞士苏黎世大学,苏黎世,ZH,瑞士
      • Posttraumatic Stress Disorder (PTSD)
        创伤后应激障碍(PTSD)
      • Sleep Disturbances and Insomnia
        睡眠障碍和失眠
      2025-04-01
      10
      A Pilot Study of Effect of Dexmedetomidine on Sleep and Inflammation in Critically Ill Patients
      丁丙诺啡对重症患者睡眠和炎症影响的试点研究
      NCT00405847
      Primary Purpose: Treatment
      主要目的: 治疗
      Allocation: Randomized  分配: 随机化
      Intervention Model: Crossover Assignment
      干预模型: 交叉分配
      Masking: Double  掩蔽:双盲
      21 Years to 85 Years (AdultOlder Adult )
      21 岁至 85 岁(成人,老年人)
      • Drug: Dexmedetomidine  药物: 德美松
      • Sleep disruption (Arousals, awakenings and sleep efficiency measured by polysomnography)
        睡眠中断(通过多导睡眠图测量的觉醒、觉醒次数和睡眠效率)
      • Circulating levels of Inflammatory cytokines (TNF-alpha, IL-1, IL-6, IL-10)
        循环中的炎症细胞因子水平(TNF-α、IL-1、IL-6、IL-10)
      • Southern Arizona VA Healthcare System, Tucson, Arizona, United States
        美国亚利桑那州图森退伍军人事务南方亚利桑那卫生医疗系统
      • Sleep  睡眠
      • Critical Illness  重症疾病
      2006-07
      11
      Dex as Analgesic Adjuvant in OSA Patients
      Dex 作为镇痛辅助剂在 OSA 患者中的应用
      NCT03613558
      Primary Purpose: Treatment
      主要目的: 治疗
      Allocation: Randomized  分配: 随机化
      Intervention Model: Parallel Assignment
      干预模型: 平行分组设计
      Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
      掩蔽: 四重(参与者、护理提供者、研究者、结果评估者)
      18 Years and older (AdultOlder Adult )
      18 岁及以上(成人,老年人)
      • Drug: Dexmedetomidine  药物: 德美松
      • Drug: Placebo  药物: 安慰剂
      • Pain Score
      • Pain Score
      • Nausea
      • (and 5 more…)  (和另外 5 项……)
      • Montefiore Medical Center, Bronx, New York, United States
        蒙特菲奥里医疗中心,纽约市,美国
      • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
      2014-07
      12
      Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea
      有阻塞性睡眠呼吸暂停病史的儿童中使用 dexmedetomidine 和 propofol
      NCT01344759
      Primary Purpose: Treatment
      主要目的: 治疗
      Allocation: Randomized  分配: 随机化
      Intervention Model: Parallel Assignment
      干预模型: 平行分配
      Masking: None (Open Label)
      掩蔽: 无(开放标签)
      12 Months to 25 Years (ChildAdult )
      12 个月至 25 岁(儿童,成人)
      • Drug: Dexmedetomidine  药物: 双异丙酚
      • Drug: Propofol  药物: 异丙酚
      • Cross Sectional Area of the Pharyngeal Airway
      • Obstructive Index Until Recovery Room Discharge
      • Respiratory Disturbance Index
      • (and 2 more…)
      • Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
      • Sleep Apnea, Obstructive
      2009-06
      13
      Dexmedetomidine Supplemented Analgesia in Patients at High-risk of Obstructive Sleep Apnea
      在高风险阻塞性睡眠呼吸暂停患者中补充丁丙诺啡镇痛
      NCT04608331
      Primary Purpose: Prevention
      主要目的: 预防
      Allocation: Randomized  分配: 随机化
      Intervention Model: Parallel Assignment
      平行分组设计
      Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
      quadruple(参与者、研究者、调查员、结果评估者)掩蔽
      18 Years to 80 Years (AdultOlder Adult )
      18 岁至 80 岁(成人、老年人)
      • Drug: Dexmedetomidine  药物: 德美多睫明
      • Drug: Placebo  药物: 醒目剂
      • The percentage of non-rapid eye movement stage 2 (N2) sleep.
      • Total sleep duration.
      • Sleep efficiency.
      • (and 8 more…)
      • Dong-Xin Wang, Beijing, Beijing, China
      • Obstructive Sleep Apnea
      • Analgesia
      • Dexmedetomidine
      • 2 more
      2021-01-29
      14
      Sedative Effects in Obstructive Sleep Apnea
      阻塞性睡眠呼吸暂停的镇静作用
      NCT01733043
      Primary Purpose: Treatment
      主要目的: 治疗
      Allocation: Randomized  分配: 随机化
      Intervention Model: Crossover Assignment
      干预模型: 交叉分配
      Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
      掩蔽: 四重掩蔽(参与者、护理提供者、研究者、结果评估者)
      18 Years and older (AdultOlder Adult )
      18 岁及以上(成人、老年人)
      • Drug: Dexmedetomidine  药物: 德美多昔布
      • Drug: Placebo  安慰剂
      • Apnea Hypopnea Index
      • Sleep Architecture
        • Obstructive Sleep Apnea
        2015-03
        15
        Does Nightly Dexmedetomidine Improve Sleep and Reduce Delirium in ICU Patients?
        夜间使用德美他嗪能否改善睡眠并减少 ICU 患者的谵妄?
        NCT01791296
        Primary Purpose: Prevention
        主要目的: 预防
        Allocation: Randomized  分配: 随机化
        Intervention Model: Parallel Assignment
        干预模型: 平行分配
        Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
        掩蔽: 四重掩蔽(参与者护理提供者研究者结果评估者)
        18 Years to 80 Years (AdultOlder Adult )
        18 岁至 80 岁(成人,老年人)
        • Drug: Dexmedetomidine  药物: 德美他淀
        • Other: Placebo  其他: 醒目剂
        • Development of delirium
        • Development of subsyndromal delirium
        • Tufts Medical Center, Boston, Massachusetts, United States
        • Maisonneuve Rosemont Hospital, Montréal, Quebec, Canada
        • Sleep Deprivation
        • Delirium
        2011-01
        16
        Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep
        使用德美他淀诱导睡眠减轻 ICU 神经功能障碍
        NCT02856594
        Primary Purpose: Treatment
        主要目的: 治疗
        Allocation: Randomized  分配: 随机化
        Intervention Model: Parallel Assignment
        干预模型: 平行分配
        Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
        掩蔽: 四重掩蔽(参与者_研究者_评估者_结果评估者)
        60 Years and older (AdultOlder Adult )
        60 岁及以上(成人,老年人)
        • Drug: Dexmedetomidine  药物: 德美松
        • Drug: Placebo  药物: 安慰剂
        • Incidence of Delirium
        • ICU Delirium/Coma-free Days
        • Severity of Delirium
        • (and 5 more…)
        • Massachusetts General Hospital, Boston, Massachusetts, United States
        • Postoperative Delirium
        • Sleep
        • Anesthesia
        2017-03-06
        17
        Sedation in Patients at Risk for Upper Airway Collapse
        患有上呼吸道塌陷风险患者的镇静
        NCT01045122
        Allocation: Randomized  分配: 随机化
        Intervention Model: Crossover Assignment
        干预模型: 交叉分配
        Masking: Double (ParticipantInvestigator)
        保密方式: 双盲(参与者和研究者)
        18 Years to 75 Years (AdultOlder Adult )
        18 岁至 75 岁(成人,老年人)
        • Drug: Propofol  药物: 异丙酚
        • Drug: Dexmedetomidine  药物: 德美多定
        • Respiratory Disturbance Index
        • University of Rochester, Rochester, New York, United States
        • Obstructive Sleep Apnea
        2006-12
        18
        Dexmedetomidine Added to Propofol for Drug Induced Sleep Endoscopy
        德美多定与丙泊酚联合用于药物诱导睡眠内镜检查
        NCT03091894
        Primary Purpose: Supportive Care
        主要目的: 支持性护理
        Allocation: Randomized  分配: 随机化
        Intervention Model: Parallel Assignment
        平行分组设计
        Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
        掩蔽: 四重(参与者_研究者_调查者_结果评估者)
        18 Years and older (AdultOlder Adult )
        18 岁及以上(成人_老年人)
        • Drug: Propofol  药物: 异丙酚
        • Drug: Dexmedetomidine  药物: 德美他淀
        • success of sedation
        • time until sufficient sedation
        • Zagazig university, Zagazig, Sharkia, Egypt
        • Obstructive Sleep Apnea of Adult
        2017-04-09
        19
        Dexmedetomidine Cycling and Sleep in the Pediatric ICU
        德美他淀循环和儿科 ICU 的睡眠
        NCT05003102
        Primary Purpose: Treatment
        主要目的: 治疗
        Allocation: Randomized  分配: 随机化
        Intervention Model: Crossover Assignment
        干预模型: 交叉分配
        Masking: Single (Outcomes Assessor)
        遮盲: 单盲(结果评估者)
        12 Years to 17 Years (Child )
        12 岁至 17 岁(儿童)
        • Drug: Dexmedetomidine Hydrochloride - Cycling
          药物: 氯化去甲肾上腺素 - 轮换
        • Drug: Fentanyl - PICU Standard
          药物: 芬太尼 - 儿科重症监护室标准
        • Drug: Dexmedetomidine Hydrochloride - PICU Standard
          药物: 氯化去甲肾上腺素 - 儿科重症监护室标准
        • Change in total sleep time as seen via an 8-lead polysomnogram
        • Change in total time in different stages of sleep as seen via an 8-lead polysomnogram
        • Change in arousal index as seen via an 8-lead polysomnogram
        • (and 2 more…)
        • Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, United States
        • Critical Illness
        • Sedation Complication
        • Delirium
        2023-02-20
        20
        Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy
        减少儿童扁桃体切除术和腺样体切除术后出现的激动,并提供镇痛
        NCT00468052
        Primary Purpose: Prevention
        主要目的: 预防
        Allocation: Randomized  分配: 随机化
        Intervention Model: Parallel Assignment
        干预模型: 平行分组设计
        Masking: Single (Participant)
        掩蔽: 单盲 (参与者)
        2 Years to 10 Years (Child )
        2 岁至 10 岁(儿童)
        • Drug: dexmedetomidine  药物: dexmedetomidine
        • Drug: fentanyl  药物: fentanyl
        • Emergence Agitation and Pain
        • Duration of Agitation
        • Hemodynamic Stability
        • (and 4 more…)
        • UMDNJ University Hospital, Newark, New Jersey, United States
        • Obstructive Sleep Apnea
        2007-03
        21
        Efficacy and Stability of Dexmedetomidine Sedation Compared to Propofol Sedation in the Drug Induced Sleep Endoscopy
        比较 dexmedetomidine 镇静与 propofol 镇静在药物诱导睡眠内镜检查中的有效性和稳定性
        NCT03892122
        Primary Purpose: Diagnostic
        主要目的: 诊断
        Allocation: Randomized  分配: 随机化
        Intervention Model: Parallel Assignment
        干预模型: 平行分配
        Masking: None (Open Label)
        掩蔽: 无(开放标签)
        18 Years to 65 Years (AdultOlder Adult )
        18 岁至 65 岁(成人,老年人)
        • Drug: Propofol Fresenius  药物: Fresenius 丙泊酚
        • Drug: Dexmedetomidine  药物: 德美多昔康
        • oxygen saturation variation during DISE
        • hert rate variation during DISE
        • systolic and diastolic blood pressure variation during DISE
        • (and 2 more…)
        • U.O.C. Otorinolaringoiatria Ospedale Di Barletta, Barletta, BAT, Italy
        • Obstructive Sleep Apnea
        2019-03-22
        22
        Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients
        低剂量德美多昔康对 ICU 机械通气患者睡眠质量的影响
        NCT03335527
        Primary Purpose: Prevention
        主要目的: 预防
        Allocation: Randomized  分配: 随机化
        Intervention Model: Parallel Assignment
        干预模型: 平行分配
        Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
        掩蔽: 四重掩蔽(参与者护理提供者研究者结果评估者)
        18 Years and older (AdultOlder Adult )
        18 岁及以上(成人,老年人)
        • Drug: Dexmedetomidine  药物: 德美松
        • Drug: Placebo (normal saline)
          药物: 安慰剂(生理盐水)
        • Sleep quality during the night of surgery.
        • Incidence of delirium within the first 7 days after surgery.
        • Sleep quality within the first 7 days after surgery.
        • (and 12 more…)
        • Peking University First Hospital, Beijing, Beijing, China
        • Aged
        • Postoperative Period
        • Intensive Care Units
        • 3 more
        2017-11-17
        23
        Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
        在儿科阻塞性睡眠呼吸暂停中,右美托咪定与丙泊酚镇静用于药物诱导睡眠内镜的比较
        NCT05303987
        Primary Purpose: Diagnostic
        主要目的: 诊断
        Allocation: Randomized  分配: 随机化
        Intervention Model: Parallel Assignment
        干预模型: 平行分组
        Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
        掩蔽: 四重盲法(参与者、研究者、评估者、结果评估者)
        3 Years to 11 Years (Child )
        3 岁至 11 岁(儿童)
        • Drug: Propofol sedation  药物: 丙泊酚镇静
        • Drug: Dexmedetomidine sedation
          药物: 布托啡诺镇静
        • Mean obstruction score at the tongue base
        • University of Michigan, Ann Arbor, Michigan, United States
        • Obstructive Sleep Apnea
        2022-10-05
        24
        Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery
        布托啡诺用于减缓胃肠道手术后的术后疼痛
        NCT02213159
        Primary Purpose: Treatment
        主要目的: 治疗
        Allocation: Randomized  分配: 随机化
        Intervention Model: Parallel Assignment
        干预模型: 平行分配
        Masking: Double (ParticipantOutcomes Assessor)
        掩蔽: 双盲(参与者和评估者)
        18 Years to 70 Years (AdultOlder Adult )
        18 岁至 70 岁(成人,老年人)
        • Drug: Dexmedetomidine  药物: 德美他明
        • Drug: Morphine  药物: 吗啡
        • Total dose of morphine consumed in Post Anesthesia Care Unit (PACU)
        • Time to first morphine requirement in PACU
        • Numeric Rating Scale (NRS) for Pain
        • (and 8 more…)
        • American University of Beirut Medical Center, Beirut, Lebanon
        • Obesity
        • Sleep Apnea
        • Diabetes
        • 1 more
        2014-07
        25
        Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA
        在高风险 OSA 患者中,小剂量 Dexmedetomidine-Esketamine 补充镇痛
        NCT06566482
        Primary Purpose: Prevention
        主要目的: 预防
        Allocation: Randomized  分配: 随机化
        Intervention Model: Parallel Assignment
        平行分组设计
        Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
        quadruple (参与者研究者研究者结果评估者) 遮盲
        18 Years to 80 Years (AdultOlder Adult )
        18 岁至 80 岁(成人,老年人)
        • Drug: Dexmedetomidine-esketamine combination
          药物: 右美托咪定-埃克塞塔明组合
        • Drug: Placebo  药物: 安慰剂
        • Subjective sleep quality during the first night after surgery.
        • Sleep structure parameters during the first night after surgery.
        • Cumulative subjective sleep quality score after surgery
        • (and 3 more…)
        • Peking University First Hospital, Beijing, Beijing, China
        • Obstructive Sleep Apnea
        • Surgery
        • Dexmedetomidine
        • 2 more
        2024-09-11
        26
        A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial
        NCT01895348
        Primary Purpose: Treatment
        Allocation: Randomized
        Intervention Model: Parallel Assignment
        Masking: Single (Participant)
        20 Years to 60 Years (Adult )
        • Drug: Propofol
        • Drug: propofol-remifentanil
        • Drug: Dexmedetomidine-remifentanil
        • Desaturation rate
        • Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of
        • Obstructive Sleep Apnea
        2012-07
        27
        Opioid-Free Anesthetic for Tonsillectomy
        NCT04528173
        Primary Purpose: Treatment
        Allocation: Randomized
        Intervention Model: Parallel Assignment
        Masking: Triple (ParticipantInvestigatorOutcomes Assessor)
        2 Years to 18 Years (ChildAdult )
        • Drug: Ketorolac
        • Drug: Dexmedetomidine
        • Drug: Morphine
        • 1 more
        • Mean FLACC (Face, Legs, Activity, Cry, Consolability) Pain Score
        • Number of Participants With Nausea, Vomiting, Pruritis
        • Number of Participants Who Sought Unplanned Medical Attention
        • (and 5 more…)
        • The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
        • University of Tennessee Health Science Center; St. Jude Children's Research Hospital, Memphis, Tennessee, United States
        • Anesthesia
        • Opioid Use
        • Tonsillitis
        • 2 more
        2020-07-22
        28
        Dexmedetomidine Enhancing the Recovery After Cardiac Surgery
        New
        NCT06907277
        Primary Purpose: Treatment
        Allocation: Randomized
        Intervention Model: Parallel Assignment
        Masking: Single (Participant)
        40 Years to 65 Years (AdultOlder Adult )
        • Drug: Dexmedetomidine
        • Drug: Fentanyl
        • Drug: Lidocain
        • Significant Enhancement of Post Operative Recovery Levels After Dexmedetomidine Administration in Cardiac Surgery.
        • Benha University, Banhā, El Qalyoubia, Egypt
        • Post-cardiac Surgery
        2024-08-30
        29
        DexmedetOmidine Complement Treats Chronic insOmnia and Improves Circadian Rhythm (DOCTOR)
        NCT04635098
        Primary Purpose: Treatment
        Allocation: Randomized
        Intervention Model: Parallel Assignment
        Masking: Double (ParticipantInvestigator)
        18 Years to 65 Years (AdultOlder Adult )
        • Drug: dexmedetomidine
        • Drug: saline
        • Sleep efficiency
        • BMAL1
        • Brain functional connectivity
        • (and 14 more…)
        • Ruijin Hospital, Shanghai, Shanghai, China
        • Chronic Insomnia
        2021-05-14
        30
        The Comparison of Dexmedetomidine and Midazolam for the Sleep in Intensive Care Unit
        NCT01966315
        Observational Model: Case-Control
        Time Perspective: Prospective
        18 Years and older (AdultOlder Adult )
          • The differences of sleep stage, sleep efficiency, arousal index and delirium between dexmedetomidine group and midazolam group
          • Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of
          • Poor Quality Sleep
          • Sleep Deprivation
          • Sleep Arousal Disorders
          • 1 more
          2013-10
          31
          Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle
          New
          NCT06824077
          Primary Purpose: Treatment
          Allocation: Randomized
          Intervention Model: Parallel Assignment
          Masking: Double (ParticipantOutcomes Assessor)
          18 Years and older (AdultOlder Adult )
          • Drug: Dexmedetomidine
          • Other: Control (placebo) group
          • Recruitment rate
          • Protocol Adherence
            • Sleep
            • Delirium
            • ICU Hospitalization
            2025-03-01
            32
            Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery
            New
            NCT06778811
            Primary Purpose: Prevention
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Triple (ParticipantCare ProviderOutcomes Assessor)
            40 Years to 75 Years (AdultOlder Adult )
            • Drug: Intraoperative infusion of dexmedetomidine
            • Drug: Intraoperative infusion of esketamine
            • Drug: Saline control
            • Sleep Quality
            • postoperative pain
            • Record postoperative analgesic medications used and the amount used for postoperative pain
            • (and 3 more…)
            • Nanjing First Hospital, Nanjing, Jiangsu, China
            • Nanjing First Hospital,Nanjing Medical University, Nanjing, Jiangsu, China
            • Sleep Wake Disorders
            • Esketamine and the Quality of Recovery
            • Dexmedetomidine
            2024-10-11
            33
            Safety and Efficacy of Esmketamine Versus Dexmedetomidine
            NCT04877639
            Primary Purpose: Other
            Allocation: Randomized
            Intervention Model: Sequential Assignment
            Masking: Single (Participant)
            3 Years to 12 Years (Child )
            • Drug: Esmketamine,Dexmedetomidine
            • Onset time, Vital signs
            • Zhongnan Hospital, Wuhan, Hubei, China
            • Osa Syndrome
            2021-05-01
            34
            The Addition of Dexmedetomidine on Postoperative Sleep for Middle-aged and Elderly Patients With Gastric Cancer
            NCT03117023
            Primary Purpose: Treatment
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
            55 Years and older (AdultOlder Adult )
            • Drug: dexmedetomidine
            • sleep time
            • pain score
            • daily sufentanil consumption
            • (and 3 more…)
            • Gastric Cancer
            2017-04-15
            35
            Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)
            NCT06192615
            Primary Purpose: Prevention
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
            60 Years and older (AdultOlder Adult )
            • Drug: Intravenous Dexmedetomidine
            • Drug: Sublingual Dexmedetomidine
            • Drug: Intravenous Placebo
            • 1 more
            • Delirium
            • Delirium
            • Delirium Severity
            • (and 9 more…)
            • Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
            • University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
            • University of Maryland School of Medicine, Baltimore, Maryland, United States
            • Massachusetts General Hospital, Boston, Massachusetts, United States
            • (and 8 more…)
            • Delirium
            2025-01-06
            36
            The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation
            NCT02162433
            Primary Purpose: Prevention
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
            3 Years to 16 Years (Child )
            • Drug: Normal Saline
            • Drug: Dexmedetomidine
            • Number of Participants With Respiratory Complications
            • Number of Participants With Emergence Agitation
            • Number of Participants With Postoperative Nausea and Vomiting (PONV)
            • (and 4 more…)
            • MEEI, Boston, Massachusetts, United States
            • Adenotonsillar Hypertrophy
            • Obstructive Sleep Apnea
            • Tonsillitis
            • 1 more
            2015-03
            37
            Establishment of Ideal IV Sedative Regimen for Successful Fiberoptic Bronchoscopy in Assessing the Site, Severity of Sleep Apnea Syndrome
            NCT02148432
            Primary Purpose: Other
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Triple (ParticipantCare ProviderInvestigator)
            20 Years to 60 Years (Adult )
            • Drug: dexmedetomidine infusion rate, 0.5 mcg/kg/hr
            • Drug: dexmedetomidine infusion rate, 1.0 mcg/kg/hr
            • Desaturation rate
            • Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of
            • Sleep Apnea Syndrome
            2014-05-19
            38
            Intranasal Dexmedetomidine and Zolpidem for Treatment of Primary Insomnia
            NCT05615727
            Primary Purpose: Treatment
            Allocation: Randomized
            Intervention Model: Crossover Assignment
            Masking: Double (ParticipantOutcomes Assessor)
            18 Years to 25 Years (Adult )
            • Drug: Dexmedetomidine
            • Drug: Zolpidem
            • Other: Placebo
            • Sleep onset latency
            • Incidence of wakening after sleep onset; Sleep quality; Wake time during sleep
            • HKU Li Ka Shing Faculty of Medicine, Hong Kong, Guangdong, China
            • Insomnia
            2022-09-01
            39
            Sleep Intervention During Acute Lung Injury
            NCT01050699
            Primary Purpose: Treatment
            Allocation: Randomized
            Intervention Model: Crossover Assignment
            Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
            18 Years to 85 Years (AdultOlder Adult )
            • Drug: Dexmedetomidine
            • Drug: Midazolam and Fentanyl
            • Specific Aim 1: To assess the short-term effect of an α2 adrenergic agent on sleep quality in critically ill patients with ALI/ARDS.
            • Specific Aim 2: To assess the short-term effect of an α2 adrenergic agent on sleep-modulating inflammatory cytokines in critically ill patients with ALI/ARDS.
            • Specific aim 3: To determine the effect of α2 adrenergic agent on the in-vitro production of sleep-modulating inflammatory cytokines by peripheral blood mononuclear cells of patients with ALI/ARDS.
            • Southern Arizona VA Health Care System, Tucson, Arizona, United States
            • University Medical Center, Tucson, Arizona, United States
            • Critical Illness
            • Sleep
            • Acute Lung Injury
            • 1 more
            2009-08
            40
            Dexmedetomidine and Melatonin for Sleep Induction for EEG in Children
            NCT04665453
            Primary Purpose: Diagnostic
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: None (Open Label)
            1 Year to 20 Years (ChildAdult )
            • Diagnostic Test: Electroencephalography
            • Diagnostic Test: Monitoring of vital functions
            • Drug: Melatonin 0,1mg/kg oral syrup
            • 2 more
            • Comparison of the three medical interventions on sleep initiation
            • Comparison of the three medical interventions on the depth of sleep and the most prominent sleep stage on EEG
            • Comparison of the three medical interventions on respiratory rate
            • (and 3 more…)
            • University Medical Centre Ljubljana, Ljubljana, Slovenia
            • Electroencephalography
            • Child
            • Dexmedetomidine
            • 3 more
            2020-09-01
            41
            Dexmedetomidine-esketamine Combined Nasal Administration and Perioperative Sleep Quality
            NCT05732064
            Primary Purpose: Prevention
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
            50 Years and older (AdultOlder Adult )
            • Drug: Dexmedetomidine
            • Drug: Esketamine
            • Drug: Normal saline
            • Subjective sleep quality (the night of surgery)
            • Subjective sleep quality (the night before and the first night after surgery)
            • Objective sleep quality - total sleep time
            • (and 5 more…)
            • Peking University First Hospital, Beijin, Bejing, China
            • Breast Cancer
            • Perioperative Period
            • Dexmedetomidine
            • 2 more
            2023-05-22
            42
            How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units
            NCT00826553
            Primary Purpose: Other
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Single (Outcomes Assessor)
            18 Years and older (AdultOlder Adult )
            • Drug: Dexmedetomidine
            • Drug: GABA agonist
            • Time spent in standard sleep stages (N1, N2, N3, REM).
            • Time spent in atypical sleep.
            • Presence of burst suppression.
            • Vanderbilt University Medical Center, Nashville, Tennessee, United States
            • Delirium
            • Respiratory Failure
            2009-01
            43
            Brain Tumor Surgery and Postoperative Delirium
            New
            NCT06863064
            Primary Purpose: Prevention
            Allocation: N/A
            Intervention Model: Single Group Assignment
            Masking: None (Open Label)
            18 Years to 80 Years (AdultOlder Adult )
            • Drug: Dexmedetomidine
            • Drug: Normal Saline
            • Assessment and Documentation of Delirium
            • Assessment and Documentation of Delirium
            • Assessment and Documentation of Delirium
            • (and 2 more…)
            • Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan
            • Brain Tumor
            2025-03-01
            44
            Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk
            NCT04817033
            Primary Purpose: Treatment
            Allocation: Randomized
            Intervention Model: Factorial Assignment
            Masking: Double (InvestigatorOutcomes Assessor)
            18 Years to 80 Years (AdultOlder Adult )
            • Procedure: Spinal anesthesia with intraoperative dexmedetomidine sedation
            • Procedure: Spinal anesthesia with intraoperative midazolam sedation
            • Drug: Dexmedetomidine
            • 1 more
            • Airway complications
            • Coughing and restlessness
            • Cardiorespiratory polygraphy
            • (and 7 more…)
            • University Hospital Split, Split, Croatia
            • Anesthesia
            • Anesthesia Complication
            • Osa Syndrome
            • 5 more
            2021-04-01
            45
            Effect of Ketorolac on Post Adenotonsillectomy Pain
            NCT03467750
            Primary Purpose: Supportive Care
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Single (Care Provider)
            2 Years to 18 Years (ChildAdult )
            • Drug: Ketorolac
            • Drug: Standard of Care
            • Post-Anesthesia Care Unit (PACU) Morphine Requirements
            • Face, Legs, Activity, Cry, Consolability (FLACC) Scale Score
            • Post-Anesthesia Care Unit (PACU) Recovery Time
            • (and 2 more…)
            • Childrens Healthcare of Atlanta, Egleston, Atlanta, Georgia, United States
            • Obstructive Sleep Apnea
            2018-07-19
            46
            Dexmedetomidine After Cardiac Surgery for Prevention of Delirium
            NCT03477344
            Primary Purpose: Treatment
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Quadruple (ParticipantCare ProviderInvestigatorOutcomes Assessor)
            65 Years and older (Older Adult )
            • Drug: Dexmedetomidine
            • Drug: Sodium chloride 0.9%
            • Delirium
            • agitation with be assessed using the Richmond agitation and sedation score
            • length of ICU stay
            • (and 13 more…)
            • Angers university hospital, Angers, France
            • CHRU de Brest, Brest, France
            • Clermont Ferrand university hospital, Clermont-Ferrand, France
            • CHU de Grenoble, Grenoble, France
            • (and 5 more…)
            • ICU Delirium
            2019-01-04
            47
            Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
            NCT02987985
            Primary Purpose: Prevention
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Triple (ParticipantInvestigatorOutcomes Assessor)
            up to 12 Years (Child )
            • Drug: Acetaminophen, gabapentin
            • Drug: Acetaminophen
            • Drug: Ketamine , Lidocaine , Dexmedetomidine
            • 4 more
            • Respiratory depression
            • Quantified opioid consumption
            • Pediatric Agitation Emergence Delirium (PAED) scale
            • (and 3 more…)
            • Royal University Hospital, Saskatoon, Saskatchewan, Canada
            • Anesthesia
            • General Anesthesia
            • Analgesics, Opioid
            • 14 more
            2017-10-15
            48
            Correlation Endoscopic View of Airway Obstruction With RRa in OSA Patients Under DEX Monitored With SedLine EEG
            NCT02639884
            Primary Purpose: Other
            Allocation: N/A
            Intervention Model: Single Group Assignment
            Masking: None (Open Label)
            19 Years and older (AdultOlder Adult )
            • Device: SedLine EEG
            • Device: RRa monitoring
            • Number of Subjects in Which Electroencephalogram (EEG) Signals is Collected
            • Number of Subjects in Which Acoustic Respiratory Rate (RRa) Signals is Collected
            • Stanford University Medical Center, Stanford, California, United States
            • Obstructive Sleep Apnea (OSA)
            2015-12
            49
            Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils
            NCT06258837
            Primary Purpose: Treatment
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Single (Outcomes Assessor)
            2 Years to 17 Years (Child )
            • Procedure: DISE-Directed Surgery
            • Procedure: Adenotonsillectomy
            • Change from Baseline Polysomnography Measures: Obstructive Apnea-Hypopnea Index (oAHI) at 6 months
            • Change from Baseline Polysomnography Measures: Total Apnea-Hypopnea Index (AHI) at 6 months
            • Change from Baseline Polysomnography Measures: REM Apnea-Hypopnea Index (REM AHI) at 6 months
            • (and 10 more…)
            • University of Michigan, Ann Arbor, Michigan, United States
            • Oregon Health and Science University, Portland, Oregon, United States
            • Otolaryngological Disease
            • Obstructive Sleep Apnea
            2024-10-04
            50
            Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management
            NCT01725607
            Primary Purpose: Treatment
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Single (Outcomes Assessor)
            18 Years to 65 Years (AdultOlder Adult )
            • Drug: general anesthesia combined with dexmedetomidine infusion
            • Procedure: general anesthesia combined with TEA
            • inflammatory cytokine secretion and postoperative sleep quality
            • amine secretion during the surgical period and hemodynamic stability
            • Department of Anesthesiology, the First Hospital of China Medical University, Shenyang, Liaoning, China
            • General Anesthesia, Thoracic Epidural Anesthesia
            2013-01
            51
            Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
            NCT05508971
            Primary Purpose: Treatment
            Allocation: Randomized
            Intervention Model: Parallel Assignment
            Masking: Single (Outcomes Assessor)
            2 Years to 17 Years (Child )
            • Procedure: DISE-Directed Surgery
            • Procedure: Adenotonsillectomy
            • Change from Baseline Polysomnography Measures: oAHI at 6 months
            • Change from Baseline Polysomnography Measures: AHI at 6 months
            • Change from Baseline Polysomnography Measures: REM AHI at 6 months
            • (and 10 more…)
            • Colorado Children's Hospital, Aurora, Colorado, United States
            • University of Michigan, Ann Arbor, Michigan, United States
            • Cincinnati Children's Hospital, Cincinnati, Ohio, United States
            • Oregon Health and Science University, Portland, Oregon, United States
            • (and 3 more…)
            • Obstructive Sleep Apnea
            • Down Syndrome
            2023-08-02
            * Study has passed its completion date and status has not been verified in more than two years.
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